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Goldilocks revisited: ER stress and pancreatic beta cell regeneration

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Step Status
Educational Materials
Release Date: Sat, 1/1/22
Termination Date: Sat, 12/31/22
Credits: 1.25
Description: There are no relevant financial relationships to disclose for this activity.

Educational Planner

Gregory A. Clines, MD, PHD
Elif A. Oral, MD,
Adina F Turcu, MD

Laura Cristina Alonso , MD
Activity Coordinator
Holly Golema
Educational Objectives: At the end of this activity, participants will be able to understand and treat diabetes and beta-cell failure.
Target Audience: This activity is appropriate for House Officers, Medical Students, Other Healthcare Professionals, Physicians
In the fields of Endocrinology.
Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Original Release Date: February 2021
Termination Date: February 2022

Additional Info:

Bibliographic Resources

  1. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429(6987):41–46.
  2. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev. Cell 2007;12(5):817–826. 
  3. Alonso L, Yokoe T, Zhang P, Scott DK, Kim SK, O’Donnell CP, Garcia-Ocana A “Glucose infusion in mice: a new model to induce beta-cell replication.” Diabetes 56(7):1792-1801. PMID: 17400928. (2007)
  4. Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano L, Zou B, O’Donnell CP, Garcia-Ocana A, and Alonso LC. “Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-SCID mice.” Diabetologia 54(3):572-82. PMID: 20936253. (2011) 
  5. Pascoe J, Hollern DA, Stamateris RE, Abbasi M, Romano LC, Zou B, O’Donnell CP, Garcia-Ocana A, and Alonso LC. “Free fatty acids block glu

Credits available:

AMA PRA Category 1: 1.25
Participation: 1.25